Anterior Mediastinal Mass Removal

Last updated: February 9, 2026

Access
PIV x2. Consider an arterial line for hemodynamic stability.
Airway
Double lumen oral ETT. Kelly clamps available (protect the ends with a bit of red rubber tubing, the kind used for stomas).
Induction
Standard
Maintenance
Gas and paralytic
Emergence
Awake
Antibiotics
Cefazolin
Position
Standard
Special
Consider the location of the mass.

Notes

If compromising SVC: may lead to SVC syndrome — place PIV in the lower extremity to ensure return to heart.

If compromising airway: consider awake fiberoptic (need to advance distal to airway obstruction).

There is concern for airway compromise/compression with induction of GA. Per Vinny Sakk, recent papers suggest GA induction with paralysis and positive-pressure ventilation can be performed safely in selected cases. In those reports, patients with airway issues were spontaneously breathing in recovery.

Myasthenia gravis: More susceptible to non-depolarizing paralytics, so be gentle. At risk for post-op respiratory failure (if pyridostigmine daily > 750 mg, BMI > 28, COPD/asthma, cannot count past 25 in one breath).